index
index
bar
index

Charlotte B. Failing Professor of Fetal Therapy and Diagnosis  
Associate Director C.S. Mott Center for Human Growth and Development,
Wayne State University School of Medicine
Department of Obstetrics and Gynecology
Center for Molecular Medicine and Genetics

bar

NEWS

 

Postdoctoral Positions Available - click here

 

New Publications

                     Jodar, M., Sendler, E., Moskovtsev, S. Librach, C., Goodrich, R., Swanson, S., Hauser, R., Diamond, M. and Krawetz, S.A. (2015) Absence of sperm RNA elements correlates with idiopathic male infertility. Science Translational Medicine. 7(295):295re6. PMID: 26157032 click for Full Text

                     Johnson, G.D., Mackie, P., Jodar, M., Moskovtsev, S. and Krawetz, S.A. (2015 Jun 13. pii: gkv591. [Epub ahead of print]) Chromatin and extracellular vesicle associated sperm RNAs. Nucleic Acids Research.PMID:26071953  click for Full Text

 

research interests

 

Transcriptionally silent RNA populations exist within mature human spermatozoa, and these messages are delivered to the oocyte at the time of fertlization. We are attempting to determine the role for these RNA in sperm. Our studies are examining potential applications in clinical fertility diagnostics as well as the re-examination of the male gamete's role in reproduction. more

 

Understanding the role of chromatin structure and how associations with the nuclear matrix, are involved in the expression of the protamine cluster is fundamental to understanding gene regulation and is a key element that will bring gene therapy from the bench to the bedside. more

 

We currently use NGS technology and a number of "home grown" in silico bioinformatics analysis methods to examine gene expression and chromatin structure. more


Chromatin and Transcription Journal Club

Meets 8:30 Thursday mornings

 

bar

 

 

title title title

author author author uthr

presenter

 
 

 

 

 

 
 

 

 

index

Dr. Stephen A. Krawetz

Home RNA in sperm protamines nuclear matrix KLab software bioinformatics SAK publications journal club microarray resources link

Postdoctoral & other Positions